|
KMID : 0363819820160010055
|
|
Korean Journal of Nuclear Medicine
1982 Volume.16 No. 1 p.55 ~ p.62
|
|
|
A Study on Effective Application of Methylenediphonate-99mTc
|
|
Kim Jae-Rok
Awh Ok-Doo
Park Kyung-Bae
Koo Hyeon-Sook
|
|
|
Abstract
|
|
|
|
Biodistribution studies has been carried out to elucidate the cause of poor bone imagings often encountered in using methylenediphosphonate(MDP)-0°Tc and to establish effective conditions in using the popular bone imaging agent. After 150 minutes from the I.V. injection of MDP-00°Tc to mice. the radioactivities accumulated at bone(B), hver(L), and stomach(S) were counted. The radiochemical purity (RCP), the volume, the radMactivity concentration and the amount of radioactivity of MDP-wn`c were controlled. Data were expressed either in %cpm/g.organ or S, con/organ. The organ distribution ratios(B/L and B/S) were correlated with the RCP, the volume of injection, the radioactivity concentration etc. Results indicated that the RCP plays a major ’role in biodistributions. High radioactivity concentration and injection of a small amount is recommended. Negligible effect was observed with the amount of radioactivity. It has been confirmed that the op-to.date methods of RCP determinations cannot seceitively detect the sharply affecting trace impurities. A particular biodistribution pattern of crossed B/L and B/S lines was observed in case of using MDP-weTc of low RCP. In such e. case, rather a higher dosage would be effective for improving the contrast between bone and liver.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
 
|